Lidex Gel

Pronunciation: floo-oh-SIN-oh-nide
Generic Name: Fluocinonide
Brand Name: Lidex

Lidex Gel is used for:

Treating inflammation and itching due to certain skin conditions. It may also be used for other conditions as determined by your doctor.

Lidex Gel is a topical adrenocortical steroid. It works by reducing skin inflammation (redness, swelling, itching, and irritation) by a way that is not clearly understood.

Do NOT use Lidex Gel if:

• you are allergic to any ingredient in Lidex Gel

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lidex Gel:

Some medical conditions may interact with Lidex Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin


• if you have had a recent vaccination; have measles, tuberculosis, chicken pox, or shingles; or have had a positive tuberculosis test


• if you are taking prednisone or similar medicines

Some MEDICINES MAY INTERACT with Lidex Gel. Because little, if any, of Lidex Gel is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Lidex Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lidex Gel:

Use Lidex Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Apply a small amount of medicine to the affected area. Gently rub the medicine in until it is evenly distributed. Wash your hands after applying Lidex Gel, unless your hands are part of the treated area.


• Do not bandage or cover the treated skin area unless directed by your doctor.


• If you miss a dose of Lidex Gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Lidex Gel.

Important safety information:

• Lidex Gel is for external use only. Do not get Lidex Gel in your eyes. If contact is made with the eyes, flush them immediately with tap water.


• If Lidex Gel is applied to the diaper area, apply a very small amount and do not use tight-fitting diapers or plastic pants.


• Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Talk with your doctor before you receive any vaccine while you are using Lidex Gel.


• Do not use Lidex Gel for other skin conditions at a later time.


• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Lidex Gel.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lidex Gel while you are pregnant. It is not known if Lidex Gel is found in breast milk. If you are or will be breast-feeding while you use Lidex Gel, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Lidex Gel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; burning, cracking, irritation, or peeling not present before you began using Lidex Gel; excessive hair growth; inflamed hair follicles; inflammation around the mouth; muscle weakness; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lidex side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face.

Proper storage of Lidex Gel:

Store Lidex Gel at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lidex Gel out of the reach of children and away from pets.

General information:

• If you have any questions about Lidex Gel, please talk with your doctor, pharmacist, or other health care provider.


• Lidex Gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lidex Gel. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Lidex resources

• Lidex Side Effects (in more detail)
• Lidex Use in Pregnancy & Breastfeeding
• Lidex Drug Interactions
• Lidex Support Group
• 6 Reviews for Lidex - Add your own review/rating

Compare Lidex with other medications

• Atopic Dermatitis
• Dermatitis
• Psoriasis

Heartgard

Dosage Form: FOR ANIMAL USE ONLY
Heartgard®

(ivermectin)

Chewables for Cats

Caution

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

INDICATION

For use in cats to prevent feline heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection, and for the removal and control of adult and immature hookworms (Ancylostoma tubaeforme and A. braziliense).

DOSAGE

Heartgard for Cats should be administered orally at monthly intervals at the recommended minimum dose level of 24 mcg of ivermectin per kg (10.9 mcg/lb) of body weight. The recommended dosage schedule for prevention of feline heartworm disease and control of hookworm is as follows:

Cat Weight lb	Heartgard for Cats Chewables per Month	Ivermectin content
For cats over 15 lb, use the appropriate combination of chewables. Heartgard for Cats is recommended for use in cats 6 weeks of age and older.
Up to 5 lb	1	55 mcg
5 to 15 lb	1	165 mcg

ADMINISTRATION

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Heartgard for Cats can be offered to the cat by hand or may be added to a small amount of cat food. If manual dosing is required, the chewable should be broken into pieces for administration. Food should be routinely available during the day of treatment administration. If cats are fasted, or if the chewable is not broken into pieces for manual dosing, then reduced absorption may result. A relationship between reduced absorption and reduced efficacy has not been established.

Care should be taken to see that the cat consumes the complete dose. Treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing with a new chewable is recommended. Fragments of chewables have occasionally been observed in the feces of some cats; efficacy of the product was not adversely affected.

Heartgard for Cats should be given at monthly intervals when mosquitoes potentially carrying infective heartworm larvae are active. The initial dose must be given within a month (30 days) after the cat's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the cat's last exposure to mosquitoes. For optimal performance, Heartgard for Cats must be given once a month on or about the same date. If treatment is delayed, whether by a few days or many, immediate treatment with Heartgard for Cats and resumption of the recommended dosing regimen will minimize the opportunity for development of adult heartworm.

It is recommended that cats should be tested for existing heartworm infection prior to starting treatment with Heartgard for Cats. Cats already infected with adult heartworms can be given Heartgard for Cats monthly to prevent further infections.

Monthly treatment with Heartgard® (ivermectin) for Cats also provides effective removal and control of adult and immature hookworms (A. tubaeforme and A. braziliense).

SAFETY

In the clinical studies involving more than 3000 doses of Heartgard for Cats, observations reported within 24 hours of treatment included vomition in ≤ 0.3% and diarrhea in ≤ 0.2% of the doses administered. There were no statistical differences between Heartgard for Cats and the product vehicle (control) for these observations.

A wide margin of safety was demonstrated in clinical trials at the recommended dose level in cats and kittens 6 weeks of age and older and in laboratory studies in cats with circulating microfilariae of D. immitis. A wide margin of safety has also been demonstrated at 3 times the recommended dose in pregnant or breeding queens and breeding toms. No adverse effects were observed in either male or female cats or their offspring in breeding studies. A 30-fold safety margin over the minimum recommended dosage was established in a single dose tolerance study. In growing kittens dosed monthly for 8 consecutive doses, one cat given 5 times the market dose vomited and a second cat in this group experienced diarrhea within 24 hours of the initial treatment. In clinical trials, many commonly used flea control products, anthelmintics, vaccines, antibiotics and steroid preparations were administered with Heartgard for Cats without incident.

Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately.

STABILITY

Heartgard Chewables for Cats are stable for 3 years when stored below 77°F (25°C) and protected from light. Store at controlled room temperature of 68°F-77°F (20°C-25°C). Excursions between 59°F-86°F (15°C-30°C) are permitted.

How is Heartgard Supplied

Heartgard for Cats is available in two dosage strengths (see DOSAGE section) for cats of different weights. Each strength comes in a convenient carton of 6 chewables, packed 10 cartons per tray.

For customer assistance, please contact Merial at 1-888-637-4251.

Marketed by

Merial Limited

3239 Satellite Blvd.

Duluth, GA 30096

Made in USA

Merial Limited, a company limited in shares registered in England and Wales (registered number 3332751) with a registered office at PO Box 327, Sandringham House, Sandringham Avenue, Harlow Business Park, Harlow, Essex CM19 5QA, England, and domesticated in Delaware, USA as Merial LLC.

NADA 141-078, Approved by the FDA.

©2010 Merial. All Rights Reserved.

Rev. 04-2010

1050-2169-03

©Heartgard and the Cat & Hand logo are registered trademarks of Merial.

PRINCIPAL DISPLAY PANEL - 6 tablet blisterpack

Heartgard®

(ivermectin)

Chewables

for Cats

Administer once a month to prevent

heartworm disease and to remove and

control infections of hookworms in cats.

For

CATS

UP TO 5 lbs

6 Chewables

Each chewable contains 55 mcg of ivermectin.

Keep this and all drugs out

of the reach of children.

Caution: Federal (U.S.A.) law restricts

this drug to use by or on the order of

a licensed veterinarian.

MERIAL

PRINCIPAL DISPLAY PANEL - 6 tablet blisterpack

Heartgard®

(ivermectin)

Chewables

for Cats

Administer once a month to prevent

heartworm disease and to remove and

control infections of hookworms in cats.

For

CATS

5 TO 15 lbs

6 Chewables

Each chewable contains 165 mcg of ivermectin.

Keep this and all drugs out

of the reach of children.

Caution: Federal (U.S.A.) law restricts

this drug to use by or on the order of

a licensed veterinarian.

MERIAL

Heartgard  ivermectin  tablet, chewable

Product Information Product Type PRESCRIPTION ANIMAL DRUG NDC Product Code (Source) 50604-4040 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ivermectin (ivermectin) ivermectin 55 ug

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color RED (red to red-brown) Score no score Shape ROUND Size 13mm Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 50604-4040-1 1 BLISTER PACK In 1 CARTON contains a BLISTER PACK 1 6 TABLET In 1 BLISTER PACK This package is contained within the CARTON (50604-4040-1) 2 50604-4040-3 1 BLISTER PACK In 1 CARTON contains a BLISTER PACK 2 1 TABLET In 1 BLISTER PACK This package is contained within the CARTON (50604-4040-3)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NADA	NADA141078	12/23/1996

Heartgard  ivermectin  tablet, chewable

Product Information Product Type PRESCRIPTION ANIMAL DRUG NDC Product Code (Source) 50604-4041 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ivermectin (ivermectin) ivermectin 165 ug

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color RED (red to red-brown) Score no score Shape ROUND Size 14mm Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 50604-4041-1 1 BLISTER PACK In 1 CARTON contains a BLISTER PACK 1 6 TABLET In 1 BLISTER PACK This package is contained within the CARTON (50604-4041-1)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NADA	NADA141078	12/23/1996

Labeler - Merial Limited (034393582)

Revised: 08/2010Merial Limited

ixabepilone Intravenous

ix-ab-EP-i-lone

Intravenous route(Powder for Solution)

Contraindicated with capecitabine in patients with AST or ALT greater than 2.5 times the upper limit of normal (ULN) or bilirubin greater than one times ULN due to increased risk of toxicity and neutropenia-related death .

Commonly used brand name(s)

In the U.S.

• Ixempra

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Mitotic Inhibitor

Chemical Class: Epothilone

Uses For ixabepilone

Ixabepilone injection belongs to the group of medicines called antineoplastics (cancer medicines). It is used to treat advanced or metastatic breast cancer (breast cancer that has already spread) after other treatments have failed. Ixabepilone is given alone or with another cancer medicine called capecitabine.

Ixabepilone interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells will also be affected by ixabepilone, other side effects may occur. Some of these may be serious and must be reported to your doctor right away.

ixabepilone is to be given only by or under the immediate supervision of your doctor.

Before Using ixabepilone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ixabepilone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ixabepilone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ixabepilone injection in the pediatric population. Efficacy has not yet been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ixabepilone injection in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ixabepilone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ixabepilone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amprenavir


• Atazanavir


• Carbamazepine


• Clarithromycin


• Delavirdine


• Dexamethasone


• Fosamprenavir


• Indinavir


• Itraconazole


• Ketoconazole


• Nefazodone


• Nelfinavir


• Phenobarbital


• Phenytoin


• Rifabutin


• Rifampin


• Ritonavir


• Saquinavir


• St John's Wort


• Telithromycin


• Voriconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ixabepilone with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ixabepilone, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of ixabepilone. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to a medicine (e.g., Taxol®) that contains Cremophor® EL or polyoxyethylated castor oil or


• Liver disease, severe or


• Neutropenia (low white blood cell count) or


• Thrombocytopenia (low platelet count)—Should not be used in patients with these conditions.

• Diabetes—Use with caution. ixabepilone may increase your chance of having nerve problems.

• Heart disease, or history of or


• Nerve problems (e.g., peripheral neuropathy)—Use with caution. May make these conditions worse.

• Liver disease, mild—Use with caution. ixabepilone should not be given with capecitabine to patients with this condition.

Proper Use of ixabepilone

A nurse or other trained health professional will give you ixabepilone in a hospital. ixabepilone is given through a needle placed in one of your veins.

ixabepilone is usually given once every 3 weeks. Each treatment usually takes about 3 hours. You may also receive medicines to help prevent possible allergic reactions to the injection.

ixabepilone often causes diarrhea, nausea, and vomiting. However, it is very important that you continue to receive the medicine even if you begin to feel ill. Your doctor may give you a medicine to help prevent these side effects.

Grapefruit and grapefruit juice may change the amount of medicine that is absorbed in the body. Do not eat grapefruit or drink grapefruit juice while you are using ixabepilone.

ixabepilone comes with a patient information insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions While Using ixabepilone

It is very important that your doctor check your progress at regular visits to make sure ixabepilone is working properly. Blood tests may be needed to check for unwanted effects.

Using ixabepilone while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

Ixabepilone injection can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood counts are low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or have painful or difficult urination.


• Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin.


• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.


• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.


• Be careful not to cut yourself when you are using sharp objects such as safety razors and fingernail or toenail cutters.


• Avoid contact sports or other situations where bruising or injury could occur.

ixabepilone may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; trouble with breathing; or chest pain after you receive the medicine.

Check with your doctor right away if you have chest pain, difficulty with breathing, a fast or pounding heartbeat, or unusual weight gain. These could be symptoms of a serious heart problem.

Ixabepilone contains alcohol, which may cause some people to become dizzy or drowsy. If any of these side effects occur, do not drive, use machines, or do anything else that could be dangerous if you are not alert.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

ixabepilone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Black, tarry stools


• body aches or pain


• burning, numbness, tingling, or painful sensations


• burning pain on urination


• chest pain


• chills


• cough


• difficult or labored breathing


• ear congestion


• fever


• headache


• loss of voice


• lower back or side pain


• nasal congestion


• painful or difficult urination


• pale skin


• red, swelling, or painful skin


• runny nose


• scaling of the skin on the hands and feet


• shortness of breath


• sneezing


• sore throat


• sores, ulcers, or white spots on the lips, tongue, or inside the mouth


• swelling of the hands, ankles, feet, or lower legs


• swollen glands


• tightness in the chest


• tingling of the hands and feet


• troubled breathing with exertion


• ulceration of the skin


• unsteadiness or awkwardness


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusual weight gain


• weakness in the arms, hands, legs, or feet


• wheezing

Less common

• Bleeding gums


• blood in the urine or stools


• confusion


• decreased urination


• dizziness


• dry mouth


• fainting


• fast heartbeat


• hives


• hoarseness


• increase in heart rate


• irritation


• itching


• joint pain, stiffness, or swelling


• lightheadedness


• pinpoint red spots on the skin


• rapid breathing


• rash


• sunken eyes


• swelling of the eyelids, face, or lips


• thirst


• trouble with swallowing


• wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bad, unusual, or unpleasant (after) taste


• bone pain


• change in taste


• cracked lips


• diarrhea


• difficulty having a bowel movement (stool)


• discoloration of the fingernails or toenails


• feeling of warmth


• hair loss or thinning of the hair


• heartburn


• lack or loss of strength


• loss of appetite


• nausea


• redness of the face, neck, arms, and occasionally, upper chest


• stomach pain


• sudden sweating


• swelling or inflammation of the mouth


• vomiting


• weight loss

Less common

• Darkening of the skin


• flaking and falling off of the skin


• sleeplessness


• trouble with sleeping


• unable to sleep


• watering of the eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: ixabepilone Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More ixabepilone Intravenous resources

• Ixabepilone Intravenous Side Effects (in more detail)
• Ixabepilone Intravenous Use in Pregnancy & Breastfeeding
• Ixabepilone Intravenous Drug Interactions
• Ixabepilone Intravenous Support Group
• 0 Reviews for Ixabepilone Intravenous - Add your own review/rating

Compare ixabepilone Intravenous with other medications

• Breast Cancer
• Breast Cancer, Metastatic

Methyl Salicylate/Menthol Cream

Pronunciation: METH-il sa-LIS-i-late/MEN-thol
Generic Name: Methyl Salicylate/Menthol
Brand Name: Trade names include Menthoderm and Thera-Gesic Plus

Methyl Salicylate/Menthol Cream is used for:

Temporary relief of minor aches and pains caused by arthritis, simple backache, strains, sprains, and bruises. It may also be used for other conditions as determined by your doctor.

Methyl Salicylate/Menthol Cream is a topical analgesic. It works by temporarily relieving minor pain.

Do NOT use Methyl Salicylate/Menthol Cream if:

• you are allergic to any ingredient in Methyl Salicylate/Menthol Cream, including oil of wintergreen

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methyl Salicylate/Menthol Cream:

Some medical conditions may interact with Methyl Salicylate/Menthol Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have had an allergic reaction to aspirin or other salicylates


• if you have a wound at the affected area or your skin is broken or damaged in any way

Some MEDICINES MAY INTERACT with Methyl Salicylate/Menthol Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Methyl Salicylate/Menthol Cream

Ask your health care provider if Methyl Salicylate/Menthol Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methyl Salicylate/Menthol Cream:

Use Methyl Salicylate/Menthol Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Apply a thin layer of medicine to the painful or sore area. You may apply up to 3 thin layers of medicine depending on your pain level. Check with your doctor or the package label if you have questions about how to apply Methyl Salicylate/Menthol Cream.


• Wash your hands immediately after using Methyl Salicylate/Menthol Cream.


• You may wash the treated area once the medicine has been absorbed into the skin.


• Do not apply Methyl Salicylate/Menthol Cream to wounds or damaged skin.


• Do not use Methyl Salicylate/Menthol Cream right after you shower or take a bath.


• Do not bandage, wrap, or cover the affected area until after the medicine has been absorbed and you have washed the area.


• Do not use Methyl Salicylate/Menthol Cream more than 3 to 4 times per day.


• If you miss a dose of Methyl Salicylate/Menthol Cream, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Methyl Salicylate/Menthol Cream.

Important safety information:

• Methyl Salicylate/Menthol Cream is for external use only. Do not get it in your eyes, ears, lips, mouth, or genital area. If you get it in any of these areas, rinse right away with cool water.


• Do not use a heating pad after you apply Methyl Salicylate/Menthol Cream.


• Do NOT use more than the recommended dose or use more often than directed without checking with your doctor.


• Do not use Methyl Salicylate/Menthol Cream over large areas of the body without checking with your doctor.


• Do not allow Methyl Salicylate/Menthol Cream to come into contact with clothing or any surface other than skin.


• If your symptoms do not get better within 7 days, if they get worse, or if they clear up and then return, check with your doctor.


• Methyl Salicylate/Menthol Cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Methyl Salicylate/Menthol Cream should not be used in CHILDREN younger than 12 years old without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Methyl Salicylate/Menthol Cream while you are pregnant. It is not known if Methyl Salicylate/Menthol Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Methyl Salicylate/Menthol Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Methyl Salicylate/Menthol Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Methyl Salicylate/Menthol Cream. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); skin redness or irritation.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Methyl Salicylate/Menthol Cream:

Store Methyl Salicylate/Menthol Cream at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Methyl Salicylate/Menthol Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Methyl Salicylate/Menthol Cream, please talk with your doctor, pharmacist, or other health care provider.


• Methyl Salicylate/Menthol Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Methyl Salicylate/Menthol Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Methyl Salicylate/Menthol resources

• Methyl Salicylate/Menthol Use in Pregnancy & Breastfeeding
• Methyl Salicylate/Menthol Drug Interactions
• Methyl Salicylate/Menthol Support Group
• 0 Reviews · Be the first to review/rate this drug

Insulin-like growth factor

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Insulin-like growth factor (IGF) is a polypeptide hormone similar to insulin. There are two types of insulin-like growth factors, IGF-1 and IGF-2, which are released upon stimulation by the growth hormone. Insulin-like growth factor binds to the IGF-1 or the IGF-2 receptor and the insulin receptor, and promotes growth and development.

Synthetic form of Insulin-like growth factor is used to treat growth failure in children, who have problems synthesizing IGF-1, which is necessary for the growth of bones and muscles.

See also

Medical conditions associated with insulin-like growth factor:

• Muscular Dystrophy
• Primary IGF-1 Deficiency

Drug List:

Increlex

Iplex

eszopiclone

es-zoe-PIK-lone

Commonly used brand name(s)

In the U.S.

• Lunesta

Available Dosage Forms:

• Tablet

Therapeutic Class: Nonbarbiturate Hypnotic

Uses For eszopiclone

Eszopiclone is used to treat insomnia (trouble in sleeping). It belongs to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system. Eszopiclone helps you get to sleep faster and sleep through the night. In general, when sleep medicines are used every night for a long time, they may lose their effectiveness. In most cases, sleep medicines should be used only for short periods of time, usually 7 to 10 days, and generally for no longer than 2 weeks.

eszopiclone is available only with your doctor's prescription.

Before Using eszopiclone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For eszopiclone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to eszopiclone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of eszopiclone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of eszopiclone in the elderly. However, dizziness, confusion, clumsiness, or unsteadiness are more likely to occur in the elderly, who may require a lower dose to help reduce unwanted effects.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking eszopiclone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using eszopiclone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Fospropofol


• Hydromorphone


• Oxycodone


• Tapentadol


• Zolpidem

Using eszopiclone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ketoconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using eszopiclone with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use eszopiclone, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of eszopiclone. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol or drug abuse, history of—Dependence on eszopiclone may develop.

• Breathing problems or lung disease or


• Depression, history of or


• Mental illness, history of—Use with caution. May make these conditions worse.

• Diseases affecting metabolism or disease involving blood circulation—Caution should be used in patients with these medical problems.

• Liver disease, severe—Use with caution. Higher blood levels of eszopiclone may result, increasing the chance of side effects.

Proper Use of eszopiclone

Take eszopiclone only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming (causing mental or physical dependence).

Take eszopiclone just before going to bed, when you are ready to go to sleep. eszopiclone works very quickly to put you to sleep.

eszopiclone should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Do not take eszopiclone when your schedule does not permit you to get a full night's sleep (8 hours). If you must wake up before this, you may continue to feel drowsy and may experience memory problems, because the effects of the medicine have not had time to wear off.

Swallow the tablet whole. Do not break, crush, or chew it.

You should not take eszopiclone with or immediately after a high-fat meal or a heavy meal.

Dosing

The dose of eszopiclone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of eszopiclone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For insomnia (trouble in sleeping):
    
    • Adults—At first, 2 milligrams (mg) at bedtime. Your doctor may increase your dose as needed.
    
    
    • Older adults—At first, 1 milligram (mg) at bedtime. Your doctor may increase your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of eszopiclone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using eszopiclone

It is very important that your doctor check your progress at regular visits to make sure eszopiclone is working properly. Blood tests may be needed to check for any unwanted effects.

eszopiclone may cause sleep-related behaviors such as driving a car (sleep-driving), walking (sleep-walking), having sex, making phone calls, or preparing and eating food while asleep or not fully awake. If these reactions occur, tell your doctor right away.

If you think you need to take eszopiclone for more than 2 weeks, be sure to discuss it with your doctor. Insomnia that lasts longer than this may be a sign of another medical problem.

eszopiclone will add to the effects of alcohol and other CNS depressants (medicines that makes you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using eszopiclone.

eszopiclone may cause some people, especially older persons, to become drowsy, dizzy, lightheaded, clumsy or unsteady, or less alert than they are normally. Even though eszopiclone is taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to eszopiclone before you drive, use machines, or do anything else that could be dangerous if you are dizzy, or are not alert or able to see well.

If you develop any unusual and strange thoughts or behavior while you are taking eszopiclone, be sure to discuss it with your doctor. Some changes that have occurred in people taking eszopiclone are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

Eszopiclone may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop taking eszopiclone and call your doctor right away if you have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using eszopiclone.

If you will be taking eszopiclone for a long time, do not stop taking it without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping completely. Stopping eszopiclone suddenly may cause withdrawal side effects.

After taking eszopiclone for insomnia, you may have difficulty sleeping (rebound insomnia) for the first few nights after you stop taking it.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

eszopiclone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Cough or hoarseness


• fever or chills


• lower back or side pain


• painful or difficult urination


• sleepiness or unusual drowsiness

Less common

• Bladder pain


• bloody or cloudy urine


• cold flu-like symptoms


• confusion


• difficult, burning, or painful urination


• discouragement


• fear or nervousness


• feeling sad or empty


• frequent urge to urinate


• irritability


• lack of appetite


• loss of interest or pleasure


• nerve pain


• nervousness


• seeing, hearing, or feeling things that are not there


• tiredness


• trouble with concentrating


• trouble with sleeping

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Change in consciousness


• loss of consciousness


• very drowsy or sleepy

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• bad, unusual, or unpleasant (after) taste


• belching


• change in taste


• dizziness


• dry mouth


• headache


• heartburn


• indigestion


• nausea


• pain


• stomach discomfort, upset, or pain

Less common

• Abnormal dreams


• accidental injury


• decreased interest in sexual intercourse


• diarrhea


• inability to have or keep an erection


• pain, cramps, or heavy bleeding (females)


• rash


• swelling of the breasts or breast soreness (in both males and females)


• vomiting

Incidence not known

• Loss of memory


• problems with memory

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: eszopiclone side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More eszopiclone resources

• Eszopiclone Side Effects (in more detail)
• Eszopiclone Dosage
• Eszopiclone Use in Pregnancy & Breastfeeding
• Eszopiclone Drug Interactions
• Eszopiclone Support Group
• 81 Reviews for Eszopiclone - Add your own review/rating

• Eszopiclone Professional Patient Advice (Wolters Kluwer)


• Eszopiclone Monograph (AHFS DI)


• Eszopiclone MedFacts Consumer Leaflet (Wolters Kluwer)


• Lunesta Prescribing Information (FDA)


• Lunesta Consumer Overview

Compare eszopiclone with other medications

• Insomnia

Jasoprim

Jasoprim may be available in the countries listed below.

Ingredient matches for Jasoprim

Primaquine

Primaquine phosphate (a derivative of Primaquine) is reported as an ingredient of Jasoprim in the following countries:

• Bangladesh

International Drug Name Search