Albocresil

Albocresil may be available in the countries listed below.

Ingredient matches for Albocresil

Policresulen

Policresulen is reported as an ingredient of Albocresil in the following countries:

• Argentina


• Brazil

International Drug Name Search

Youfenil

Youfenil may be available in the countries listed below.

Ingredient matches for Youfenil

Flufenamic Acid

Flufenamic Acid aluminium salt (a derivative of Flufenamic Acid) is reported as an ingredient of Youfenil in the following countries:

• Japan

International Drug Name Search

Abocoat

Abocoat may be available in the countries listed below.

Ingredient matches for Abocoat

Hydrocortisone

Hydrocortisone 17α-butyrate (a derivative of Hydrocortisone) is reported as an ingredient of Abocoat in the following countries:

• Japan

International Drug Name Search

doxorubicin

Generic Name: doxorubicin (DOX oh ROO bi sin)

Brand names: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

What is doxorubicin?

Doxorubicin is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Doxorubicin is used to treat different types of cancers that affect the breast, bladder, ovary, thyroid, stomach, lungs, bones, nerve tissues, bones, muscles, joints, and soft tissues. Doxorubicin is also used to treat Hodgkin's disease and certain types of leukemia.

Doxorubicin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about doxorubicin?

You should not use this medication if you are allergic to doxorubicin or similar medications (Cerubidine, Ellence, Idamycin, Novantrone), or if you have an untreated or uncontrolled infection, severe liver disease, severe heart problems, or if you have recently had a heart attack. Doxorubicin can have serious side effects on your heart. Before you are treated with doxorubicin, tell your doctor if you have a history of heart disease, heart rhythm disorder, congestive heart failure, or heart attack.

Also tell your doctor about all other medicines you use, especially about any other cancer medications or treatments you have received (including radiation).

Do not use doxorubicin if you are pregnant. It could harm the unborn baby. Doxorubicin can lower blood cells that help your body fight infections. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection. Do not receive a "live" vaccine while using doxorubicin, or you could develop a serious infection.

Using doxorubicin may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

What should I discuss with my healthcare provider before taking doxorubicin?

Before you are treated with doxorubicin, tell your doctor about all other cancer medications and treatments you have received, including radiation. You should not use this medication if you are allergic to doxorubicin or similar medications (Cerubidine, Ellence, Idamycin, Novantrone), or if you have:

• 
  

  an untreated or uncontrolled infection (including mouth sores);

  
  


• 
  

  severe liver disease;

  
  


• 
  

  severe heart problems; or

  
  


• 
  

  if you have recently had a heart attack.

  
  

To make sure you can safely receive doxorubicin, tell your doctor if you have any of these other conditions:

• 
  

  liver or kidney disease;

  
  


• 
  

  a weak immune system caused by prior cancer treatments;

  
  


• 
  

  heart disease, a heart rhythm disorder, congestive heart failure; or

  
  


• 
  

  if you have ever had a heart attack.

  
  

Using doxorubicin may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk. FDA pregnancy category D. Do not use doxorubicin if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant or plan to become pregnant. Use birth control to prevent pregnancy while you are receiving doxorubicin. Doxorubicin can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using doxorubicin.

How should I take doxorubicin?

Doxorubicin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Doxorubicin is sometimes given together with other cancer medications. You may be given other medications to prevent nausea, vomiting, or infections.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when doxorubicin is injected.

If any of this medication accidentally gets on your skin, wash it thoroughly with soap and warm water.

Doxorubicin can lower blood cells that help your body fight infections. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.

See also: Doxorubicin dosage (in more detail)

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your doxorubicin injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking doxorubicin?

Do not receive a "live" vaccine while using doxorubicin, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Doxorubicin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:

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  pain, burning, irritation, or skin changes where the injection was given;

  
  


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  feeling short of breath, even with mild exertion;

  
  


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  swelling, rapid weight gain (especially in your face and midsection);

  
  


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  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  
  


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  fast, slow, or uneven heartbeats;

  
  


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  anxiety, sweating, severe shortness of breath, wheezing, gasping for breath;

  
  


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  chest pain, sudden cough, cough with foamy mucus, rapid breathing, coughing up blood;

  
  


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  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  
  


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  lower back pain, blood in your urine, urinating less than usual or not at all;

  
  


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  numbness or tingly feeling around your mouth, weak pulse, overactive reflexes, confusion, fainting;

  
  


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  muscle weakness, tightness, or contraction;

  
  


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  fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  
  


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  pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

  
  


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  easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

  
  

Less serious side effects may include:

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  missed menstrual periods;

  
  


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  darkening of your skin or nails;

  
  


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  temporary hair loss;

  
  


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  feeling weak or tired;

  
  


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  mild nausea, diarrhea; or

  
  


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  eye redness, puffy eyelids.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Doxorubicin Dosing Information

Usual Adult Dose for Breast Cancer:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Neuroblastoma:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Hodgkin's Disease:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Ovarian Cancer:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Wilms' Tumor:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Stomach Cancer:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Acute Lymphoblastic Leukemia:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Lymphoma:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Osteosarcoma:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Bladder Cancer:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Acute Myeloblastic Leukemia:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Thyroid Cancer:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Bronchogenic Carcinoma:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Soft Tissue Sarcoma:

When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 IV every 21 to 28 days. Alternatively, 60 to 75 mg/m2 IV once every 21 days. The lower doses are recommended for patients with inadequate marrow reserves due to old age, prior therapy, or neoplastic marrow infiltration.

Usual Adult Dose for Multiple Myeloma:

(In combination with other chemotherapeutic agents as a part of the VAD regimen)
9 mg/m2/day IV continuous infusion on days 1 through 4

Usual Pediatric Dose for Malignant Disease:

35 to 75 mg/m2 as a single dose repeated every 21 days, or 20 to 30 mg/m2 once weekly, or 60 to 90 mg/m2 given as a continuous infusion over 96 hours every 3 to 4 weeks.

What other drugs will affect doxorubicin?

Many drugs can interact with doxorubicin. Below is just a partial list. Tell your doctor if you are using:

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  acetaminophen (Tylenol);

  
  


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  an antibiotic or antifungal medication;

  
  


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  auranofin (Ridaura) or gold injections to treat arthritis;

  
  


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  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


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  dexrazoxane (Totect, Zinecard);

  
  


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  progesterone (Prometrium);

  
  


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  rosiglitazone (Avandia, Avandamet, Avandaryl);

  
  


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  an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others;

  
  


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  birth control pills or hormone replacement therapy;

  
  


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  cholesterol medications such as atorvastatin (Lipitor, Caduet), simvastatin (Zocor, Simcor, Vytorin), and others;

  
  


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  drugs that weaken your immune system, such as adalimumab (Humira), certolizumab (Cimzia), clozapine (Clozaril, FazaClo), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade), and others;

  
  


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  heart rhythm or blood pressure medicine such as amiodarone (Cordarone, Pacerone), benazepril (Lotensin), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), enalapril (Vasotec), labetalol (Normodyne, Trandate), lisinopril (Prinivil, Zestril), methyldopa (Aldomet), quinapril (Accupril), ramipril (Altace), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;

  
  


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  HIV/AIDS medications;

  
  


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  non-steroidal anti-inflammatory drugs (NSAIDs) such as (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

  
  


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  other cancer medications, especially cyclophosphamide Cytoxan, Cytoxan Lyophilized, Neosar), cytarabine (Cytosar, DepoCyt, Tarabine), etoposide (Etopophos, VePesid), paclitaxel (Taxol, Onxol), sorafenib (Nexavar); or

  
  


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  seizure medications such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), divalproex (Depakote), phenobarbital (Solfoton), phenytoin (Dilantin), valproic acid (Depakene, Stavzor).

  
  

This list is not complete and there may be other drugs that can interact with doxorubicin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More doxorubicin resources

• Doxorubicin Dosage
• Doxorubicin Use in Pregnancy & Breastfeeding
• Doxorubicin Drug Interactions
• Doxorubicin Support Group
• 2 Reviews for Doxorubicin - Add your own review/rating

• doxorubicin Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Adriamycin Prescribing Information (FDA)


• Doxorubicin MedFacts Consumer Leaflet (Wolters Kluwer)


• Doxorubicin Prescribing Information (FDA)


• Doxorubicin Hydrochloride Monograph (AHFS DI)


• Rubex Prescribing Information (FDA)

Compare doxorubicin with other medications

• Acute Lymphoblastic Leukemia
• Acute Myeloblastic Leukemia
• Bladder Cancer
• Breast Cancer
• Cancer
• Hodgkin's Lymphoma
• Lung Cancer
• Lymphoma
• Multiple Myeloma
• Neuroblastoma
• Osteosarcoma
• Ovarian Cancer
• Soft Tissue Sarcoma
• Stomach Cancer
• Thyroid Cancer
• Wilms' Tumor

Where can I get more information?

• Your doctor or pharmacist can provide more information about doxorubicin.

Allopurinol DHA

Allopurinol DHA may be available in the countries listed below.

Ingredient matches for Allopurinol DHA

Allopurinol

Allopurinol is reported as an ingredient of Allopurinol DHA in the following countries:

• Singapore

International Drug Name Search

Chewable Vitamin C

Chewable Vitamin C may be available in the countries listed below.

Ingredient matches for Chewable Vitamin C

Ascorbic Acid

Ascorbic Acid is reported as an ingredient of Chewable Vitamin C in the following countries:

• Israel

International Drug Name Search

Osmoclear

Osmoclear may be available in the countries listed below.

Ingredient matches for Osmoclear

Naphazoline

Naphazoline is reported as an ingredient of Osmoclear in the following countries:

• Peru

Naphazoline hydrochloride (a derivative of Naphazoline) is reported as an ingredient of Osmoclear in the following countries:

• Colombia

International Drug Name Search

Furazolidon

Furazolidon may be available in the countries listed below.

Ingredient matches for Furazolidon

Furazolidone

Furazolidone is reported as an ingredient of Furazolidon in the following countries:

• Poland


• Romania

International Drug Name Search